Rearranged NFKB-2 genes in lymphoid neoplasms code for constitutively active nuclear transactivators
نویسندگان
چکیده
منابع مشابه
Lymphoid Neoplasms
One of the confusing aspects of the lymphoid neoplasms concerns the use of the descriptive terms "lymphocytic leukemia" and "lymphoma." Leukemia is used for lymphoid neoplasms presenting with widespread involvement of the bone marrow, usually accompanied by the presence of large numbers of tumor cells in the peripheral blood. Lymphoma, on the other hand, is used to describe proliferations arisi...
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BACKGROUND Allogeneic bone marrow transplantation (BMT) has been used in patients with low-grade lymphoma (LGL) and chronic lymphocytic leukemia (CLL) with the goal of achieving long-term disease-free survival. PATIENTS AND METHODS Twenty-nine patients with these diagnoses (LGL = 19, CLL = 10) received allogeneic BMT between September 1995 and January 1999. Median age was 42 (range 20-52) yea...
متن کاملGenes Code for Proteins 2
• Recessive mutations are due to loss-of-function by the protein product. • Dominant mutations result from a gain-of-function. • Testing whether a gene is essential requires a null mutation (one that completely eliminates its function). • Silent mutations have no effect, either because the base change does not change the sequence or amount of protein, or because the change in protein sequence h...
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Eosinophilia in the absence of allergies, asthma, drug reactions, parasitic infections and connective tissue diseases can be eosinophilic clonal disorders, lymphoma or myeloproliferative disorders. Hypereosinophilia with the persistence of eosinophils ≥1500 /mm³ in blood or more than 20% of eosinophils in the bone marrow may be observed in many reactive or clonal disorders, the result of which ...
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Hepatitis C virus (HCV) is one of the viruses known to cause hepatic cancer. HCV is also believed to be involved in malignant lymphoma. In this paper, we investigated characteristics of malignant lymphoma cases that were anti-HCV antibody (HCV-Ab) positive. We were able to perform pathological examinations on 13 out of 14 HCV-positive cases. Of these, lymphoid tissues of 10 stained positive for...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1995
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.15.9.5180